Anticancer Potential of Natural Isoquinoline Alkaloid Berberine
نویسندگان
چکیده
منابع مشابه
Podophyllotoxin: a novel potential natural anticancer agent
Objective: The aim of the present review is to give an overview about the role, biosynthesis, and characteristics of Podophyllotoxin (PTOX) as a potential antitumor agent with particular emphasis on key biosynthesis processes, function of related enzymes and characterization of genes encoding the enzymes. Materials and Methods: Google scholar, PubMed and Scopus were searched for literatures wh...
متن کاملIntegration of microRNA–mRNA profiles and pathway analysis of plant isoquinoline alkaloid berberine in SGC-7901 gastric cancers cells
Purpose Berberine (BBR) is a traditional Chinese medicine normally used for gastroenteritis, and recent research found that it could fight against tumors. In this study, we focused on integrating miRNA sequencing and RNA sequencing of SGC-7901 gastric cancer cells treated by BBR to elucidate their underlying mechanisms. Materials and methods WST-1 assay and flow cytometry were used to check t...
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Ionizing radiations are used regulary to treat various tumors since the discovery of X-rays by Wilhelm Conrad Röntgen in the year 1895 and approximately 40% of patients are cured by radiotherapy and 50% of the patients receive radiotherapy during their disease [1,2]. It is used to treat tumors or as an adjuvant or neoadjuvant therapy and in several instances it is the only modality to treat tum...
متن کاملBerberine, an isoquinoline alkaloid in herbal plants, protects pancreatic islets and serum lipids in nonobese diabetic mice.
Type 1 diabetes (T1D) damages pancreatic islets, gradually causing chronic complications. This study investigated the berberine effect on T1D in vivo. Nonobese diabetic (NOD) mice were grouped and administered 50, 150, and 500 mg of berberine/kg of body weight over 14 weeks using consecutive tube feeding. Changes in pancreatic islets, serum insulin, berberine, and lipid levels were determined. ...
متن کاملIsoquinoline Alkaloid Berberine Exerts its Antineoplastic Activity by Inducing Molecular DNA Damage in HeLa Cells: A Comet Assay Study
Molecular damage of DNA plays an important role in the cell killing and several anti-neoplastic agents exert their cytotoxic effects by inducing DNA damage in the cancer cells. DNA damaging effect of various concentrations of berberine chloride (BCL), an isoquinoline alkaloid was studied in HeLa cells by alkaline comet assay. The DNA damage has been expressed as olive tail moment (OTM). Incubat...
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ژورنال
عنوان ژورنال: Journal of Exploratory Research in Pharmacology
سال: 2021
ISSN: 2572-5505
DOI: 10.14218/jerp.2021.00005